DOES YOUR NMN SUPPLEMENT HAVE GMP ON THE BOTTLE? OURS DOES
AND, HERE IS WHY IT IS IMPORTANT. Many supplements claim that their product is
manufactured in a GMP facility but is it displayed on the bottle? If not, it
is because the manufacturer will not allow the claim to be made if they are
NOT a GMP facility. All Genex Formulas products are manufactured in a GMP
certified facility and we proudly display this on our labeling. This is
extremely important since GMP (which stands for 'Good Manufacturing Practices)
are a set of best practices for dietary supplement manufacturing in the United
States. Establish, maintained, and updated by the U.S. these regulations
establish the baseline requirements for dietary supplement companies and
manufacturers looking to produce dietary supplement products. Covering
everything from labeling and packaging to ingredient sourcing and formulation
- GMPs have been put in place for each step of the dietary supplement
manufacturing process. Along with acting as a quality control measure, GMPs
requirements help ensure that dietary supplement products consistently meet
specifications for purity, strength, and composition. GMPs are overseen and
enforced by a number of well-established and credentialed third party
auditors, like NSF. WHAT IS NMN? NMN is an entirely natural compound found in
our bodies. Various food sources also contain this compound in minuscule
amounts. Edamame which has one of the higher contents, only show less than
1.9mg/100g. NMN is a direct and potent NAD+ supplement. Mice given an oral
supplement of NMN showed increased liver NAD+ levels in just 10 minutes and
showed an increase in muscle tissue by 30 minutes. Increased NAD+ levels
stimulate energy DNA repair and SIRTUIN activity. SIRTUINS are the longevity-
genes shown to be active during caloric restriction and life-extension in many
animal models. NAD+ helps to breakdown food like sugars into energy. Promotes
Healthy Cardiovascular Function. DNA Repair - NAD+ is used to repair broken
DNA strands. SIRTUIN Activator - NAD+ is required for our longevity genes to
work. NMN is THE compound used by Harvard Scientists to reverse some signs of
aging tissue in mice that started the rush to NAD supplements. THE SCIENCE
Scientists have now confirmed a direct link between falling NAD+ levels and
aging in both animals and human subjects. A breakthrough study published by
Harvard scientists in 2013 showed for the first time that some aspects of
aging might be reversible. After treating old mice with NMN, several biometric
markers that were subsequently measured resembled those of young mice: "the
human equivalent of a 60-year old with markers resembling that of a 20-year
old". The research and understanding into NAD+ metabolomics are ongoing, but
what the science has highlighted thus far, is the importance of supporting and
maintaining our NAD+ levels. A long-term evaluation of oral supplementation of
NMN in mice was found to be effective at improving NAD+ levels safely. Mice
supplemented with NMN vs. a control group showed notable age-associated
differences in mass, energy, lipid, gene expression changes, mitochondrial
oxygen use, eye function, bone density with no apparent toxic effects. This
product is not intended to diagnose, treat, cure or prevent and diseases. Is
there a correlation between falling NAD levels and aging? Scientists have
discovered that as we get older, our NAD+ levels steadily decrease, and by the
time we get to our late 70s &80s, our NAD+ levels appear to be much lower,
than those of younger people. The science is starting to clearly show a
definite correlation between falling NAD levels and an age-related decline in
health & wellness. In 2013 Harvard researchers published a study, where they
were able to reverse some parts of aging by treating old mice with NMN, a
direct NAD+ precursor supplement. After ten days of treatment, key biometrics
markers measured resembled those of much younger mice. For the first time, we
have real evidence that some aspects of aging may be reversible. In 2017 the
same team published a follow-up article. It demonstrated a new understanding
of how NAD+ is not only used to repair damaged DNA but how it also stimulates
the repair process. It does this by blocking another protein called DBC1 that
interferes with the PARP-1 DNA Repair enzyme. Read more New NMN Transporter
Slc12a8 Found How NMN is taken up into cells has not been entirely clear.
However, a recent study has identified that Slc12a8 is highly expressed and
regulated by NAD+ in the small intestine. When NAD+ levels are low, the cells
respond by turning on more Slc12a8 transporters. It has been further shown
that Slc12a8 specifically transports NMN and not NR. The study demonstrates
that Slc12a8 has a critical role in regulating intestinal and systemic NAD+
supply. Read more The Power of Three! Why NMN, Resveratrol & Berberine is a
Powerful Combination So far, at least three major longevity pathways have been
identified by researchers. The SIRTUIN gene regulators that silence genes and
repair DNA, the AMPK activated pathway, and the mTOR pathway which influences
cell division and growth. The power of three, positively promote these
synergistic pathways to better our chances of a favorable outcome when
supplemented together. NMN is excellent, as it provides the fuel for Sirtuins
and the substrate for DNA repair. However, Resveratrol is also very important
as it independently activates Sirtuins and to a lesser extent, inhibits mTOR
activity. Finally, Berberine which is one of the better studied natural plant
extracts is a good AMPK activator that stimulates mitochondrial biogenesis and
offers other benefits by turning on genes similar to those turned on by
exercise. Read more NMN Nicotinamide Mononucleotide NAD Supplement NMN is an
entirely natural compound found in our bodies. Various food sources also
contain this compound in minuscule amounts. Edamame which has one of the
higher contents, only show less than 1.9mg/100g. NMN is a direct and potent
NAD+ supplement. Mice given an oral supplement of NMN showed increased liver
NAD+ levels in just 10 minutes and showed an increase in muscle tissue by 30
minutes. Increased NAD+ levels stimulate energy, DNA repair, and SIRTUIN
activity. SIRTUINS are the longevity-genes shown to be active during caloric
restriction and life-extension in many animal models. Resveratrol with
BioPerine At Genex, we chose to use an all-natural and organic source of
Resveratrol that was extracted from Japanese knotweed (also known as Polygonum
cuspidatum root) which contains 50% Trans-Resveratrol. Resveratrol has several
remarkable properties that help to support good health. Most commonly,
Resveratrol is known as the longevity supplement found in red wine and
generally as an effective antioxidant. Resveratrol is also the most potent
naturally occurring direct SIRTUIN activating compound. Berberine AMPK
Activator AMPK Activator Berberine is a natural plant-based compound found in
several different plants, including Barberry (Berberis vulgaris). Berberine is
known as a direct AMPK activator. The AMPK pathway, in short, is one of the
things that happens during exercise, the expression of a set of genes known to
promote longevity. Both human and animal studies show. Berberine may also help
support healthy cholesterol, gut, brain, heart, and inflammation. Berberine is
a general health and wellness supplement that has been used as a traditional
herb for thousands of years. Read more NMN Nicotinamide Mononucleotide NAD
Supplement Resveratrol with BioPerine Extra Strength Berberine AMPK Activator
Sirtuin Activator - Longevity Support ✓ ✓ Antioxodent ✓ ✓ ✓ Promotes Healthy
Immune Funtion ✓ ✓ ✓ AMPK Activator ✓ ✓ GMO Free ✓ ✓ ✓ Glutten Free ✓ ✓ ✓
Is Discontinued By Manufacturer : No
Product Dimensions : 2.5 x 2.5 x 4.25 inches; 2.08 Ounces
Item model number : GFNMN500MG1
Department : Unisex-adult
Date First Available : February 29, 2020
Manufacturer : Genex Formulas
There are many cheaper alternative sources to buy NMN today, but are you getting what you paid for? If the price for NMN is too good to be true, it probably is not NMN. We use pharmaceutical grade NMN in our product, so make sure you get what you pay for!
FULLY STABILIZED - Our NMN comes in a completely shelf-stable non-refrigerated form. We use opaque jars and desiccant packs to protect it from light and moisture to ensure it maintains maximum potency.
Certified 99% Pure NMN - Direct NAD+ Precursor Supplement SIRTUIN Activator - NAD+ is required for our longevity genes to work.
Dr. Sinclair's Recent trials show Old Mice treated with NMN restored blood vessel capillary density.
All of our products are manufactured in a GMP and NSF certified facility.
